Microfluidics and LOC simulations

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Involved People F. Sirsi, A. Leo G. Maruccio

Omnics group is experienced in Finite elements method (FEM) calculations with the aim of parameters optimization during the development of Lab On Chip platforms or electronic interfaces between samples and measurement setup. For example, when designing a Printed Circuit Board (PCB), we evaluate the potential cross talk between the on-chip signals (Figure 1). On the other hand, microfluidic simulations (Figure 2) include calculations on the behavior of a solute diffusion inside a system of microfluidic channels after hydrodynamic focusing, such as those performed in the framework of the European Research project MADIA (Magnetic Diagnostic Assay for neurodegenerative diseases).

Figure 1: Electric field (a) and capacitive matrix (b) for the PCB fitting a 50 pins female connector. Color scale reported on the right side is in pF and it’s possible to notice the very poor interaction between wires farer away than the first neighbors.
Figure 2: Hydrodynamic focusing geometry (a) and calculated diffusion (b). The inflow was optimized to obtain a reasonable solution confinement. The region labelled reference and sensing domains represents the positions of the transducers able to detect particles presence during the flow.

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